Meet the Cast of 'Painkiller' Starring Uzo Aduba and Matthew Broderick - Netflix Tudum

  • Who’s Who

    Meet the Villains and Victims of the Opioid Crisis Drama ‘Painkiller’

    Uzo Aduba, Matthew Broderick, Taylor Kitsch and more make up the cast of the tense limited series.

    By Tara Bitran
    Dec. 8, 2023

Painkiller puts a sharp focus on the pain wrought by America’s opioid epidemic. The limited series, premiering Aug. 10, charts the skyrocketing business of Purdue Pharma’s OxyContin campaign in the US — a movement which quickly became a health care crisis that’s still ravaging America today.

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With a cast that includes Uzo Aduba, Matthew Broderick, and Taylor Kitsch, Painkiller recounts the “several moments when this epidemic could’ve been stopped,” co-showrunner Noah Harpster told Netflix during production. Micah Fitzerman-Blue also serves as co-showrunner, with Eric Newman (Narcos), Alex Gibney, and Pete Berg executive producing.

Learn more about the cast who play the perpetrators, victims, and truth-seekers whose lives are altered by the introduction of OxyContin in the series below. While some characters — like the Sacklers and US Attorney John Brownlee — are inspired by real people, others are fictional, representing the experiences of so many.

Uzo Aduba as Edie Flowers in ‘Painkiller’ Season 1.

Uzo Aduba

as Edie Flowers
About the Character

Edie Flowers is a no-nonsense lawyer working for the US attorney’s office in Roanoke who’s investigating the new drug OxyContin. She attempts to bring a case against Purdue Pharma, the company that makes OxyContin and is widely blamed for creating the opioid epidemic in America.

Aduba’s character serves as the series’ anchor. “She’s our guide as we unpack the complexities of what Purdue did and how the opioid epidemic started and then spread,” Berg previously told Netflix.

Previously In

Orange Is the New Black, In Treatment, Mrs. America, Steven Universe, Candy Jar, Miss Virginia, Really Love, Solos, National Champions, Showing Roots, Lightyear, Beats, American Pastoral, and Tallulah

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Really Love
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Matthew Broderick as Richard Sackler in ‘Painkiller’ Season 1.

Matthew Broderick

as Richard Sackler
About the Character

Richard Sackler is the scion of the billionaire family and a senior executive at Purdue Pharma. He’s the nephew of Arthur Sackler, the founder of Purdue. After Arthur passes away and saddles his family with debt, it’s Richard’s idea to make opiates the company’s profit engine. 

In Broderick’s portrayal of him, Sackler “certainly doesn’t think that he’s the bad guy in the story of his life, and one of the really interesting things about Matthew is that he’s just an incredibly nice and kind person, which he brings to playing a character who’s morally questionable,” Berg told Netflix. “He’s found a whole other dimension to what could have been a somewhat one-note character.”

Previously In

Ferris Bueller’s Day Off, WarGames, Election, The Lion King, The Producers, Glory, The Freshman, The Cable Guy, The Tale of Despereaux, The Stepford Wives, Godzilla, Daybreak, BoJack Horseman, and Inspector Gadget

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Taylor Kitsch as Glen Kryger in ‘Painkiller’ Season 1.

Taylor Kitsch

as Glen Kryger
About the Character

Glen Kryger is a hardworking family man and small business owner whose life is upended after he suffers an injury at work and his doctor prescribes him OxyContin.

 

Casting Kitsch in the series felt like a family reunion for Berg — they first worked together on Friday Night Lights. “Taylor is like my little brother,” Berg told Netflix.

Previously In

Friday Night Lights, True Detective, The Terminal List, The Defeated, The Normal Heart, Waco, 21 Bridges, American Assassin, Savages, John Carter, The Covenant, and X-Men Origins: Wolverine

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The Defeated
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Savages
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West Duchovny as Shannon Schaeffer in ‘Painkiller’ Season 1.

West Duchovny

as Shannon Schaeffer
About the Character

Shannon Schaeffer is an ex-college athlete who’s desperate to leave her parents’ home in Ohio. She finds a job as a new recruit to the Purdue sales team. As her role becomes increasingly lucrative, her conscience comes into play.

Previously In

Saint X, The Magicians, Linoleum, A Mouthful of Air, Vegas High, The Report, Sick, and The X-Files

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Carolina Bartczak as Lily Kryger in Painkiller Season 1.

Carolina Bartczak

as Lily Kryger
About the Character

Lily Kryger is Glen’s wife. She is very much in love with him and tries her best to support her husband after his injury. But she is pushed to the brink by his increasingly dangerous and harmful behaviors.

Previously In

X-Men: Apocalypse, Moonfall, Brick Mansions, An Audience of Chairs, The Bold Type, Business Ethics, White Lie, Most Dangerous Game, Within These Walls, Hall, Death of a Ladies’ Man, Be Mine, Valentine, A Charming Valentine, Christmas in Love, The Mysteries of Alfred Hedgehog, Covert Affairs, The Listener, Karma’s a B*tch!, The Secret Life of Marilyn Monroe, and Air Crash Investigation

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Jack Mulhern as Tyler Kryger in Painkiller Season 1.

Jack Mulhern

as Tyler Kryger
About the Character

Tyler Kryger is Glen’s 17-year-old stepson who is prone to angst and rebellion. He struggles with guilt because Glen’s accident happened while they were arguing at their family-owned tire shop.

Previously In

The Society, Mare of Easttown, Wu-Tang: An American Saga, Unconformity, and Odd Man Rush

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Dina Shihabi as Britt Hufford in ‘Painkiller’ Season 1.

Dina Shihabi

as Britt Hufford
About the Character

Britt Hufford is a veteran sales rep for Purdue who mentors Shannon. Beneath her unflinching devotion to the company lies deep insecurity.

Previously In

Altered Carbon, Archive 81, Tom Clancy’s Jack Ryan, Daredevil, BKPI, Ghosts of Beirut, Agent Stoker, Madam Secretary, MVP, Ramy, and Catching Dust

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Altered Carbon
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Clark Gregg as Arthur Sackler in Painkiller Season 1.

Clark Gregg

as Arthur Sackler
About the Character

Arthur Sackler is the patriarch of the Sackler family and founder of Purdue. He is the one who realized that the big money in medicine was in sales and marketing. He appears to Richard as an apparition throughout the series to guide his nephew in his handling of the family legacy.

Previously In

The Marvel Cinematic Universe (films and series including Iron Man, Agents of S.H.I.E.L.D., Thor, The Avengers, Captain Marvel, Ultimate Spider-Man, and What If.. ?), The New Adventures of Old Christine, Much Ado About Nothing, Very Good Girls, The To Do List, Labor Day, Brightest Star, Live by Night, Spinning Man, The Conners, Moxie, Being the Ricardos, Run Sweetheart Run, How I Met Your Father, Florida Man, The West Wing, Hoot, In the Land of Women, Choke, 500 Days of Summer, Mr. Popper’s Penguins, As the World Turns, Clear and Present Danger, The Usual Suspects, Sports Night, Sex and the City, The Practice, and Will & Grace

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Florida Man
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Moxie
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John Rothman as Mortimer Sackler in ‘Painkiller’ Season 1.

John Rothman as Mortimer Sackler (left) in Season 1 of Painkiller

 

John Rothman

as Mortimer Sackler
About the Character

Mortimer Sackler is the co-owner of Purdue Pharma and Richard Sackler’s uncle. 

Previously In

The Devil Wears Prada, Ghostbusters, Big, Taxi, Gettysburg, Jingle All the Way, Picture Perfect, Pollock, Say It Isn’t So, Welcome to Mooseport, Prime, United 93, One Mississippi, The Report, Bombshell, and Enchanted

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Tyler Ritter as John Brownlee in ‘Painkiller’ Season 1.

Tyler Ritter

as US Attorney John Brownlee
About the Character

US Attorney John Brownlee is Edie Flowers’ new boss, who is a clean-cut straight-shooter. She works hard to convince him to take down Purdue in pursuit of true justice.

Previously In

Merry Happy Whatever, The McCarthys, Arrow, Agents of S.H.I.E.L.D., Modern Family, Grey’s Anatomy, Young & Hungry, NCIS, Loosely Exactly Nicole, Hot in Cleveland, The Good Doctor, and An Evergreen Christmas

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Painkiller premieres on Netflix Aug. 10.

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All About Painkiller

  • Taylor Kitsch Says Signing onto ‘Painkiller’ with Pete Berg was a ‘No Brainer’
    The 'Friday Night Lights' alum digs deep in the new limited series.
  • And the moral awakening it represents for her ambitious sales rep character.
  • “There was no face to it that I knew of until that moment."
  • Watch Broderick star as a pharmaceutical billionaire in the limited series.
  • The limited series chronicles America’s opioid crisis.

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